Scientist I, Structural Biology
W2 Contract
Location: Redwood City, CA - Onsite Role
Job Summary:
As a Scientist, you will support our Structural Biology (X-ray crystallography) team in multiple oncology therapeutic programs by generating protein crystal structures. Working from the bench, you will apply expertise in protein purification, identification and optimization of crystallization conditions, and routine production and harvesting of co-crystals of protein and small molecules.
Requirements and Qualifications:
- Ph.D and 0-2 years of experience
- Experience with protein handling, characterization, and storage (FPLC or HPLC techniques like SEC and affinity chromatography. PAGE, quantitation via Bradford and nanodrop, etc.).
- Experience growing and harvesting protein crystals; prior use of crystallographic software suites (CCP4, Phenix) and visualization software (PyMOL, Chimera) is highly preferred.
- Experience with protein-protein complexes, including antibodies/Fabs, molecular glues, and PROTACs
- Able to follow written protocols and document research progress.
- Rigorous, quantitative, detail-oriented experimentalist
- Excellent written and verbal communication skills
- Principled team player interested in a fast-paced biotech environment
- Demonstrated willingness to learn and improve processes
Preferred Qualifications:
- Experience with biophysical characterization such as MS, Thermal Shift Analysis, and SPR
- Experience with protein-ligand crystallization and refinement
- Experience in protein expression, including construct design and protein engineering
Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.
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Desired Skills and Experience
Structural Biology, X-ray crystallography, oncology, protein handling, protein characterization, FPLC, HPLC, affinity chromatography, PAGE, Bradford, nanodrop, CCP4, Phenix, PyMOL, Chimera, protein-protein complexes, Thermal Shift Analysis, SPR, protein-ligand crystallization, protein expression, protein engineering
